American Airlines flight AA 2221: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 08:55 Charlotte (CLT) 10:52 Indianapolis (IND)
AA 2221 Non-stop Boeing 737-800 (738) 1:57 Effective 2025-10-26 through 2025-11-01
Daily 08:55 Charlotte (CLT) 10:45 Indianapolis (IND)
AA 2221 Non-stop Airbus A320 (320) 1:50 Effective 2025-12-03 through 2025-12-17
Daily 08:55 Charlotte (CLT) 10:33 Indianapolis (IND)
AA 2221 Non-stop Airbus A319 (319) 1:38 Effective 2025-12-18 through 2026-01-05
Daily 08:55 Charlotte (CLT) 10:50 Indianapolis (IND)
AA 2221 Non-stop Airbus A320 (320) 1:55 Effective 2026-01-06 through 2026-02-11
Daily 08:55 Charlotte (CLT) 10:51 Indianapolis (IND)
AA 2221 Non-stop Boeing 737-800 (738) 1:56 Effective from 2026-02-12
Daily 12:15 Indianapolis (IND) 14:00 Charlotte (CLT)
AA 2221 Non-stop Airbus A320 (320) 1:45 Effective 2026-01-06 through 2026-02-11
Daily 12:16 Indianapolis (IND) 14:00 Charlotte (CLT)
AA 2221 Non-stop Boeing 737-800 (738) 1:44 Effective from 2026-02-12
Daily 12:18 Indianapolis (IND) 14:00 Charlotte (CLT)
AA 2221 Non-stop Airbus A319 (319) 1:42 Effective 2025-12-18 through 2026-01-05
Daily 12:19 Indianapolis (IND) 14:00 Charlotte (CLT)
AA 2221 Non-stop Boeing 737-800 (738) 1:41 Effective 2025-10-26 through 2025-11-01
Daily 12:20 Indianapolis (IND) 14:00 Charlotte (CLT)
AA 2221 Non-stop Airbus A320 (320) 1:40 Effective 2025-12-03 through 2025-12-17
Daily 16:02 Chicago O'Hare (ORD) 3 18:45 Dallas Fort Worth (DFW)
AA 2221 Non-stop Boeing 737-800 (738) 2:43 Effective 2025-11-02 through 2025-12-02
Daily 16:08 Atlanta (ATL) N 17:43 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:35 Effective 2025-07-05 through 2025-08-05
Daily 16:09 Atlanta (ATL) N 17:49 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:40 Effective 2025-06-05 through 2025-07-04
Daily 16:14 Atlanta (ATL) N 18:02 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:48 Effective 2025-10-06 through 2025-10-25
Daily 16:25 Atlanta (ATL) N 18:03 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:38 Effective 2025-08-06 through 2025-09-02
Daily 16:33 Atlanta (ATL) N 18:18 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:45 Effective 2025-09-03 through 2025-10-05
Daily 17:55 Atlanta (ATL) N 19:50 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:55 Effective 2025-05-05 through 2025-06-04
Daily 18:52 Atlanta (ATL) N 20:45 Los Angeles (LAX)
AA 2221 Non-stop Airbus A321 (321) 4:53 Valid until 2025-05-04
Daily 21:25 Dallas Fort Worth (DFW) 23:50 Chicago O'Hare (ORD) 3
AA 2221 Non-stop Boeing 737-800 (738) 2:25 Effective 2025-11-02 through 2025-12-02
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This flight number is listed as serving the following routes:


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American Airlines flight AA 2221: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA2221
08:55
Charlotte (CLT)

10:52
Indianapolis (IND)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:57, non-stop
Boeing 737-800 (738)
American Airlines AA2221
08:55
Charlotte (CLT)

10:45
Indianapolis (IND)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Airbus A320 (320)
American Airlines AA2221
08:55
Charlotte (CLT)

10:33
Indianapolis (IND)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Airbus A319 (319)
American Airlines AA2221
08:55
Charlotte (CLT)

10:50
Indianapolis (IND)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Airbus A320 (320)
American Airlines AA2221
08:55
Charlotte (CLT)

10:51
Indianapolis (IND)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Boeing 737-800 (738)
American Airlines AA2221
12:15
Indianapolis (IND)

14:00
Charlotte (CLT)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Airbus A320 (320)
American Airlines AA2221
12:16
Indianapolis (IND)

14:00
Charlotte (CLT)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Boeing 737-800 (738)
American Airlines AA2221
12:18
Indianapolis (IND)

14:00
Charlotte (CLT)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Airbus A319 (319)
American Airlines AA2221
12:19
Indianapolis (IND)

14:00
Charlotte (CLT)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:41, non-stop
Boeing 737-800 (738)
American Airlines AA2221
12:20
Indianapolis (IND)

14:00
Charlotte (CLT)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:40, non-stop
Airbus A320 (320)
American Airlines AA2221
16:02
Chicago O'Hare (ORD) 3

18:45
Dallas Fort Worth (DFW)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:43, non-stop
Boeing 737-800 (738)
American Airlines AA2221
16:08
Atlanta (ATL) N

17:43
Los Angeles (LAX)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:35, non-stop
Airbus A321 (321)
American Airlines AA2221
16:09
Atlanta (ATL) N

17:49
Los Angeles (LAX)
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:40, non-stop
Airbus A321 (321)
American Airlines AA2221
16:14
Atlanta (ATL) N

18:02
Los Angeles (LAX)
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:48, non-stop
Airbus A321 (321)
American Airlines AA2221
16:25
Atlanta (ATL) N

18:03
Los Angeles (LAX)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:38, non-stop
Airbus A321 (321)
American Airlines AA2221
16:33
Atlanta (ATL) N

18:18
Los Angeles (LAX)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:45, non-stop
Airbus A321 (321)
American Airlines AA2221
17:55
Atlanta (ATL) N

19:50
Los Angeles (LAX)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:55, non-stop
Airbus A321 (321)
American Airlines AA2221
18:52
Atlanta (ATL) N

20:45
Los Angeles (LAX)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:53, non-stop
Airbus A321 (321)
American Airlines AA2221
21:25
Dallas Fort Worth (DFW)

23:50
Chicago O'Hare (ORD) 3
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:25, non-stop
Boeing 737-800 (738)
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Parallax here
This flight number is listed as serving the following routes:
  • Atlanta (ATL) - Los Angeles (LAX)
  • Dallas Fort Worth (DFW) - Chicago O'Hare (ORD)
  • Indianapolis (IND) - Charlotte (CLT)
All American Airlines flights
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