Delta Air Lines flight DL 5643: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 08:00 New York LaGuardia (LGA) C 10:30 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:30 Effective 2025-10-26 through 2025-12-23
Mon,Sun 08:00 New York LaGuardia (LGA) C 10:30 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:30 Effective 2026-01-04 through 2026-01-05
Daily 08:00 New York LaGuardia (LGA) C 10:35 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:35 Effective from 2026-01-06
Daily 08:59 New York LaGuardia (LGA) C 11:24 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:25 Effective 2025-07-07 through 2025-08-30
Daily 08:59 New York LaGuardia (LGA) C 11:24 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:25 Effective 2025-09-01 through 2025-09-07
Daily 08:59 New York LaGuardia (LGA) C 11:31 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:32 Effective 2025-09-08 through 2025-10-25
Mon-Fri,Sun 09:10 New York LaGuardia (LGA) C 11:40 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:30 Effective 2025-05-07 through 2025-05-23
Mon-Fri,Sun 09:10 New York LaGuardia (LGA) C 11:40 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:30 Effective 2025-05-26 through 2025-06-06
Sun 09:13 New York LaGuardia (LGA) C 11:38 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:25 Operates only on 2025-07-06
Mon-Fri,Sun 09:14 New York LaGuardia (LGA) C 11:39 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:25 Effective 2025-06-08 through 2025-07-04
Mon,Tue,Fri,Sat 09:20 New York LaGuardia (LGA) C 11:51 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:31 Effective 2025-05-02 through 2025-05-06
Sat 10:05 New York LaGuardia (LGA) C 12:32 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:27 Effective 2025-06-14 through 2025-07-05
Sat 11:10 New York LaGuardia (LGA) C 13:39 Louisville (SDF) DL 5643 Non-stop Embraer EMB 175 (E75) 2:29 Effective 2025-05-10 through 2025-06-07
Daily 11:45 Louisville (SDF) 13:58 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:13 Effective 2025-10-26 through 2025-12-23
Mon,Sun 11:45 Louisville (SDF) 13:58 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:13 Effective 2026-01-04 through 2026-01-05
Daily 11:45 Louisville (SDF) 13:57 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:12 Effective from 2026-01-06
Sun 12:05 Louisville (SDF) 14:15 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:10 Operates only on 2025-05-25
Sun 12:18 Louisville (SDF) 14:34 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:16 Operates only on 2025-07-06
Mon-Fri,Sun 12:19 Louisville (SDF) 14:35 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:16 Effective 2025-06-08 through 2025-07-04
Mon-Fri,Sun 12:20 Louisville (SDF) 14:32 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:12 Effective 2025-05-07 through 2025-05-23
Mon-Fri,Sun 12:20 Louisville (SDF) 14:32 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:12 Effective 2025-05-26 through 2025-06-06
Mon-Fri,Sun 12:20 Louisville (SDF) 14:38 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:18 Effective 2025-07-07 through 2025-09-07
Daily 12:20 Louisville (SDF) 14:33 New York LaGuardia (LGA) C DL 5643 Non-stop Embraer EMB 175 (E75) 2:13 Effective 2025-09-08 through 2025-10-25
Daily 15:50 New York LaGuardia (LGA) C 18:23 Louisville (SDF) DL 5643 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:33 Effective 2025-12-24 through 2026-01-03

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This flight number is listed as serving the following routes:

Louisville (SDF) - New York LaGuardia (LGA)

All Delta Air Lines flights

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Delta Air Lines flight DL 5643: Multiple routes

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FLIGHT SCHEDULE

Direct Flights:

Delta Air Lines DL5643

08:00

New York LaGuardia (LGA) C

10:30

Louisville (SDF)

Effective 2025-10-26 through 2025-12-23

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:30, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

08:00

New York LaGuardia (LGA) C

10:30

Louisville (SDF)

Effective 2026-01-04 through 2026-01-05

Mon

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 2:30, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

08:00

New York LaGuardia (LGA) C

10:35

Louisville (SDF)

Effective from 2026-01-06

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:35, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

08:59

New York LaGuardia (LGA) C

11:24

Louisville (SDF)

Effective 2025-07-07 through 2025-08-30

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:25, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

08:59

New York LaGuardia (LGA) C

11:24

Louisville (SDF)

Effective 2025-09-01 through 2025-09-07

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:25, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

08:59

New York LaGuardia (LGA) C

11:31

Louisville (SDF)

Effective 2025-09-08 through 2025-10-25

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:32, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

09:10

New York LaGuardia (LGA) C

11:40

Louisville (SDF)

Effective 2025-05-07 through 2025-05-23

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:30, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

09:10

New York LaGuardia (LGA) C

11:40

Louisville (SDF)

Effective 2025-05-26 through 2025-06-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:30, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

09:13

New York LaGuardia (LGA) C

11:38

Louisville (SDF)

Operates only on 2025-07-06

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 2:25, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

09:14

New York LaGuardia (LGA) C

11:39

Louisville (SDF)

Effective 2025-06-08 through 2025-07-04

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:25, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

09:20

New York LaGuardia (LGA) C

11:51

Louisville (SDF)

Effective 2025-05-02 through 2025-05-06

Mon

Tue

Wed
-

Thu
-

Fri

Sat

Sun
-

Duration: 2:31, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

10:05

New York LaGuardia (LGA) C

12:32

Louisville (SDF)

Effective 2025-06-14 through 2025-07-05

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:27, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

11:10

New York LaGuardia (LGA) C

13:39

Louisville (SDF)

Effective 2025-05-10 through 2025-06-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:29, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

11:45

Louisville (SDF)

13:58

New York LaGuardia (LGA) C

Effective 2025-10-26 through 2025-12-23

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:13, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

11:45

Louisville (SDF)

13:58

New York LaGuardia (LGA) C

Effective 2026-01-04 through 2026-01-05

Mon

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 2:13, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

11:45

Louisville (SDF)

13:57

New York LaGuardia (LGA) C

Effective from 2026-01-06

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:12, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:05

Louisville (SDF)

14:15

New York LaGuardia (LGA) C

Operates only on 2025-05-25

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 2:10, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:18

Louisville (SDF)

14:34

New York LaGuardia (LGA) C

Operates only on 2025-07-06

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 2:16, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:19

Louisville (SDF)

14:35

New York LaGuardia (LGA) C

Effective 2025-06-08 through 2025-07-04

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:16, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:20

Louisville (SDF)

14:32

New York LaGuardia (LGA) C

Effective 2025-05-07 through 2025-05-23

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:12, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:20

Louisville (SDF)

14:32

New York LaGuardia (LGA) C

Effective 2025-05-26 through 2025-06-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:12, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:20

Louisville (SDF)

14:38

New York LaGuardia (LGA) C

Effective 2025-07-07 through 2025-09-07

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:18, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

12:20

Louisville (SDF)

14:33

New York LaGuardia (LGA) C

Effective 2025-09-08 through 2025-10-25

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:13, non-stop
Embraer EMB 175 (E75)

Delta Air Lines DL5643

15:50

New York LaGuardia (LGA) C

18:23

Louisville (SDF)

Effective 2025-12-24 through 2026-01-03

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:33, non-stop
Embraer EMB 170 / EMB 175 (E70)

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This flight number is listed as serving the following routes:

Louisville (SDF) - New York LaGuardia (LGA)

All Delta Air Lines flights

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